Compare Doctor-Supervised Weight-Loss Programs
Compare the top online programs that connect you with licensed providers for doctor-supervised weight-loss care — and find the plan that fits your goals and budget. Independent comparison, not medical advice.
Online GLP-1 programs make it possible to start doctor-supervised medical weight loss with semaglutide (Ozempic®, Wegovy®) or tirzepatide (Mounjaro®, Zepbound®) — all from home, with licensed providers. We scored the leading providers against the same five criteria. Here are the top 10.
Starting at $99/month
- 100% online — eligibility check in minutes
- Care from U.S.-licensed clinicians
- Medication shipped to your door (if eligible)
- Ongoing support and check-ins
Starting at $129/month
- Transparent membership pricing
- Licensed provider consultations
- Compounded GLP-1 options
- Ongoing support
Starting at $129/month
- Compounded tirzepatide & semaglutide
- Licensed U.S. provider oversight
- Quick online intake — no clinic visit
- Medication shipped direct to your door
Starting at $199/month
- Compounded semaglutide & tirzepatide
- Injectable or oral GLP-1 options
- No insurance required
- Licensed U.S. provider oversight
Starting at $89/month
- 100% online eligibility check
- U.S.-licensed clinicians
- Medication shipped to your door (if eligible)
- Straightforward monthly membership
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- Huge range of weight-loss & fitness supplements
- No prescription needed
- Trusted retailer since 1999
- Frequent deals + free-shipping offers
Starting at $119/month
- 100% online eligibility check
- U.S.-licensed clinicians
- Medication shipped to your door (if eligible)
- Ongoing support throughout
Starting at $109/month
- 100% online eligibility check
- U.S.-licensed clinicians
- Medication shipped to your door (if eligible)
- Ongoing check-ins and support
systemStarting at $95/month
- 100% online eligibility check
- U.S.-licensed clinicians
- Medication shipped to your door (if eligible)
- Ongoing support included
Starting at $115/month
- 100% online eligibility check
- U.S.-licensed clinicians
- Medication shipped to your door (if eligible)
- Ongoing support included
What you need to know about weight-loss injections
GLP-1 receptor agonists — semaglutide (the active ingredient in Ozempic® and Wegovy®) and tirzepatide (Mounjaro® and Zepbound®) — mimic a natural gut hormone that helps regulate appetite and blood sugar. They slow digestion and reduce hunger, so most people eat less without constant willpower battles, which supports both fat loss and weight maintenance.
Get $50 Off + Free ShippingVisit SiteDo they really work?
In large clinical trials, people taking semaglutide lost on average roughly 15% of their body weight over about 68 weeks, and tirzepatide around 20%, when combined with diet and lifestyle changes. Results vary by person, and treatment should always be guided by a licensed provider. (Source: U.S. FDA)
Is weight-loss injection therapy suitable for you?
Eligibility is determined by a licensed provider, but GLP-1 treatment is generally considered for adults with:
- A BMI of 30 or higher (obesity), or
- A BMI of 27 or higher (overweight) with a related condition such as high blood pressure, high cholesterol, or type 2 diabetes
Each program includes a quick online health review so a licensed provider can confirm whether treatment is appropriate for you.
Get $100 Off + Free ShippingVisit SiteHow to Choose a Weight-Loss Medication Program
GLP-1 medications like Ozempic, Wegovy, Mounjaro and Zepbound — and their compounded semaglutide and tirzepatide counterparts — have transformed medical weight loss. Programs differ a lot on price, medication type, and support. Here's what to look for.
Brand-name vs. compounded medication
Brand-name GLP-1s (Wegovy, Zepbound, Ozempic, Mounjaro) are FDA-approved but often pricier and supply-limited. Compounded semaglutide or tirzepatide can be more affordable and accessible, but should only come from programs working with reputable, licensed pharmacies. A licensed provider should be involved either way.
What's actually included in the price
Some programs bundle the medication into one flat fee; others charge a membership plus the medication separately. Always confirm the all-in monthly cost before committing.
Insurance vs. cash-pay
If you have coverage, a program with an insurance team can dramatically reduce the cost of brand-name GLP-1s. If you don't, look for transparent cash-pay or flat-fee programs built for that.
Support makes the difference long-term
Weight loss lasts when it's supported. Provider check-ins, coaching, and responsive support help you manage dosing, side effects, and habits — and keep results once you reach your goal.
Get $75 Off + Free ShippingVisit SiteFrequently asked questions
What are GLP-1 weight-loss medications?
GLP-1 receptor agonists (such as semaglutide — Ozempic/Wegovy — and tirzepatide — Mounjaro/Zepbound) are prescription medications that help regulate appetite and blood sugar. They're prescribed by licensed providers for weight management.
Do I need a prescription?
Yes. GLP-1 medications are prescription-only. Each program here connects you with a U.S.-licensed provider who reviews your health information to determine if treatment is appropriate for you.
What's the difference between brand-name and compounded GLP-1s?
Brand-name GLP-1s (Wegovy, Zepbound, Ozempic, Mounjaro) are FDA-approved finished products. Compounded semaglutide and tirzepatide are prepared by licensed compounding pharmacies and are often more affordable or accessible, but availability and regulations vary. A licensed provider should always oversee your care.
How much does a GLP-1 program cost?
It varies widely — from around $99/month for some compounded plans to several hundred dollars when brand-name medication is bundled in. Insurance can lower brand-name costs significantly. Always confirm your all-in cost during intake.
How did you rank these programs?
We score every program against the same five criteria — medical oversight, medication options, transparent pricing, support, and reputation — and no company can pay for a higher ranking.
Is this medical advice?
No. This page is for educational and informational purposes only and is not medical advice. Always consult a licensed healthcare provider about whether a GLP-1 medication is right for you.